Butyrate Frequently Asked Questions

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Butyrate is a postbiotic, a natural short-chain fatty acid compound made by beneficial gut bacteria during the digestion of dietary fibers. It fuels the cells that line the large intestine, strengthens the gut barrier, and helps decrease inflammation. Butyrate also supports the gut–brain axis, promoting healthy communication between the digestive system and the nervous system. Butyrate produced in the human gut or taken as a supplement is safe and beneficial, making it an important part of gut and brain health.

Sodium butyrate (C₄H₇NaO₂) is the sodium salt of butyric acid—a white, crystalline, highly water-soluble solid with only a mild rancid odor. Strong butyrate odor arises mainly when the salt is acidified to free butyric acid. It is readily soluble in water and should be stored in a cool, dry, and sealed container. 

We have ran an extensive analysis of all clinical studies with butyrate to determine the optimal dose. Based on 18 studies and the benefits associated with oral administration of butyrate, we recommend 2g dose per day (three capsules in the morning and three in the evening)  potentially increasing to 4g if well tolerated. 

At Stella Maris Therapeutics, we don't just develop and sell products but we build lasting relationships with our customers and we learn from them. We learned from patients with Parkinson's disease that their symptoms improve if they eat cheese before going to bed. Butyrate can make up as much as 1% of total weight of cheese. While indirect, these findings suggest that butyrate may provide benefits if taken before bedtime. Therefore, we recommend taking the product in the morning and in the evening with water. 

Sodium butyrate is generally recognized as safe and well tolerated. Some individuals may experience mild digestive discomfort, such as gas, bloating, loose stools, or abdominal cramps—effects that are common with many gut health supplements as the body adjusts. No serious health issues have been documented at normal supplemental doses. Starting with a lower dose and gradually increasing may help minimize discomfort and improve tolerance.

Stella Maris Therapeutics uses only the highest quality ingredients that undergo rigorous quality control testing. We never add artificial flavors or colors to mask the natural aroma. This ensures that our product remains pure and effective. Because of this, our customers don’t have to worry about unwanted side effects that can come from artificial additives. While butyrate naturally has a strong scent, we use a sodium butyrate  form, which helps reduce its ability to become volatile and emit a strong pungent smell while retaining all health benefits. 

We use capsules that are specifically formulated to withstand stomach acid and small intestine tract. The capsules are made of cellulose and gellan gum - two natural products that are specifically digested by bacteria once they reach the large intestine (colon). Using our encapsulation strategy, we ensure that butyrate reaches the side where it will be utilized by intestinal cells to promote gut health. 

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